Regional distribution of substance P in the brain of the rat

Brain Res. 1976 Nov 5;116(2):299-305. doi: 10.1016/0006-8993(76)90907-0.


Using a sensitive radioimmunoassay we have studied the regional distribution of substance P. The level of substance P is higher in the mesencephalon, hypothalamus and preoptic area than in other regions of the brain. Substance P is found in especially high concentrations in the reticular part of the substantia nigra and the interpeduncular nucleus. It is present in large amounts in several septal, preoptic and hypothalamic nuclei as well.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Chemistry*
  • Brain Stem / analysis
  • Female
  • Hypothalamus / analysis
  • Mesencephalon / analysis
  • Preoptic Area / analysis
  • Rats
  • Substance P / analysis*
  • Substantia Nigra / analysis


  • Substance P