Some controversies in planning and analysing multi-centre trials

Stat Med. 1998 Aug 15-30;17(15-16):1753-65; discussion 1799-800. doi: 10.1002/(sici)1097-0258(19980815/30)17:15/16<1753::aid-sim977>;2-x.


It is shown that a rational approach to planning multi-centre trials will lead to an unequal distribution of patients across centres. Consequently different approaches to estimation will yield different estimates. However, some such approaches are not reasonable and it is concluded that multi-centre trials are less problematic than is commonly supposed.

Publication types

  • Review

MeSH terms

  • Bias
  • Data Interpretation, Statistical*
  • Effect Modifier, Epidemiologic
  • Humans
  • Multicenter Studies as Topic / standards*
  • Patient Selection*
  • Planning Techniques
  • Reproducibility of Results
  • Research Design / standards*