The factor V Leiden mutation increases the risk of venous thrombosis in patients with inflammatory bowel disease

Gastroenterology. 1998 Oct;115(4):830-4. doi: 10.1016/s0016-5085(98)70253-7.


Background & aims: Thromboembolic disease is a significant cause of morbidity and mortality in patients with inflammatory bowel disease (IBD). The aim of this study was to determine the incidence and possible association of the factor V Leiden mutation with the development of thrombosis in patients with IBD.

Methods: This retrospective study included 11 patients with IBD and arterial or venous thrombosis and 51 patients with IBD and no history of thrombosis who were matched for age, sex, ethnic/racial origin, and type of IBD (controls). The presence of the factor V Leiden mutation was determined by coagulation assay and confirmed by a polymerase chain reaction method.

Results: Four of 11 IBD patients (36%) with thrombosis and 2 of 51 IBD controls (4%) were heterozygotes for the factor V Leiden mutation (relative risk, 14.00; 95% confidence interval, 1.55-169.25; P = 0.009, Fisher exact test). All thrombotic events in the patients with activated protein C resistance were venous with a calculated prevalence of 50% (4 of 8 patients) and a relative risk of venous thrombosis in IBD patients with factor V Leiden of 23 (95% confidence interval, 2-294; P = 0.005).

Conclusions: In patients with IBD, inheritance of the factor V Leiden mutation results in a significant increased risk of venous thrombosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Drug Resistance
  • Factor V / genetics*
  • Female
  • Heterozygote
  • Humans
  • Incidence
  • Inflammatory Bowel Diseases / complications*
  • Inflammatory Bowel Diseases / genetics*
  • Male
  • Middle Aged
  • Mutation / physiology*
  • Protein C / pharmacology
  • Protein C / physiology
  • Retrospective Studies
  • Risk Factors
  • Thrombophlebitis / epidemiology
  • Thrombophlebitis / etiology*


  • Protein C
  • factor V Leiden
  • Factor V