The c-Fes family of protein-tyrosine kinases

Crit Rev Oncog. 1998;9(1):43-62. doi: 10.1615/critrevoncog.v9.i1.40.


The human c-fes protooncogene encodes a protein-tyrosine kinase (c-Fes) distinct from c-Src, c-Abl and other nonreceptor tyrosine kinases. Although originally identified as the cellular homolog of several transforming retroviral oncoproteins, Fes was later found to exhibit strong expression in myeloid hematopoietic cells and to play a direct role in their differentiation. Recent work has shown that Fes exhibits a more widespread expression pattern in both developing and adult tissues, suggesting a general physiological function for this kinase and its closely related homolog, Fer. This review highlights the unique aspects of Fes structure, regulation, and function that set it apart from other tyrosine kinase families.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Division
  • Fusion Proteins, gag-onc / genetics
  • Fusion Proteins, gag-onc / metabolism
  • Gene Expression Regulation, Developmental
  • Hematopoietic Stem Cells / enzymology
  • Humans
  • Oncogene Proteins / metabolism
  • Protein-Tyrosine Kinases*
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-bcr
  • Proto-Oncogene Proteins c-fes
  • src Homology Domains


  • Fusion Proteins, gag-onc
  • Oncogene Proteins
  • Proto-Oncogene Proteins
  • proto-oncogene protein c-fes-fps
  • Protein-Tyrosine Kinases
  • FES protein, human
  • Proto-Oncogene Proteins c-fes
  • v-fps oncogene protein, Fujinami sarcoma virus
  • BCR protein, human
  • Proto-Oncogene Proteins c-bcr