The G-protein betagamma complex

Cell Signal. 1998 Jul;10(7):447-55. doi: 10.1016/s0898-6568(98)00006-0.


The vast majority of signalling pathways in mammalian cells are mediated by heterotrimeric (alpha betagamma) G proteins. Reviewed here is regulation of signal transduction by the betagamma complex at different protein interfaces: subunit-subunit, receptor-G protein and G protein-effector. The role of diverse beta and gamma subunit types in achieving specificity in signalling and potentially unidentified functions for these subunits also are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • GTP-Binding Proteins* / chemistry
  • GTP-Binding Proteins* / genetics
  • GTP-Binding Proteins* / metabolism
  • Gene Expression
  • Humans
  • Molecular Sequence Data
  • Protein Conformation
  • Receptors, Cell Surface / metabolism


  • Receptors, Cell Surface
  • GTP-Binding Proteins