Localization of the neurokinin 1 (NK-1) receptor in the human antrum and duodenum

Neurosci Lett. 1998 Aug 28;253(1):49-52. doi: 10.1016/s0304-3940(98)00618-1.


A newly available antibody to the neurokinin-1 receptor (NK-1r) has made it possible to determine the distribution of the NK-1r receptor in human tissue. In the present study the distribution of the NK-1r and substance P have been determined in the human antrum and duodenum by immunocytochemistry. The NK-1r was present on myenteric and submucosal neurons and nerve fibers of the gastro-enteric nervous system. In addition, the receptor was present on spindle-shaped cells in the circular muscle layer, endothelial cells and a population of mucosal cells. In the submucosal plexus NK-1r immunoreactive neurons were surrounded by substance P containing fibers. These results indicate an extensive cellular expression of the NK-1r in the human antrum and duodenum.

MeSH terms

  • Animals
  • Antibodies
  • Antibodies, Monoclonal
  • Antibody Specificity
  • Duodenum / cytology*
  • Duodenum / innervation
  • Gastric Mucosa / cytology*
  • Gastric Mucosa / innervation
  • Guinea Pigs
  • Humans
  • Immunohistochemistry
  • Intestinal Mucosa / cytology*
  • Intestinal Mucosa / innervation
  • Myenteric Plexus / cytology*
  • Neurons / cytology*
  • Pyloric Antrum / cytology
  • Pyloric Antrum / innervation
  • Receptors, Neurokinin-1 / analysis*


  • Antibodies
  • Antibodies, Monoclonal
  • Receptors, Neurokinin-1