Novel implications of the potential role of selenium on antioxidant status in streptozotocin-induced diabetic mice

Biomed Pharmacother. 1998;52(2):89-95. doi: 10.1016/S0753-3322(98)80008-5.


Levels of blood glucose, lipid peroxidation, glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) activities and blood selenium levels were determined in streptozotocin (STZ)-induced diabetic mice. The effect of oral administration of sodium selenite was studied on the above parameters. Diabetes caused hyperglycemia (2.8-fold increase) with a significant increase in the malondialdehyde levels (89% in liver and 83% in blood) and GST activity (55%) and marked decreases in GSH levels (approximately 73% in blood and 79% in liver) in the 5th week after STZ treatment as compared to normal control animals. Treatment of STZ-induced diabetic mice with sodium selenite changed these parameters to near control values in almost all cases. These results suggest that selenium plays a role in reducing the oxidative stress associated with diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism
  • Diabetes Mellitus, Experimental / blood*
  • Diabetes Mellitus, Experimental / drug therapy*
  • Glutathione / blood
  • Glutathione Peroxidase / blood
  • Glutathione Transferase / blood
  • Lipid Peroxidation / drug effects
  • Male
  • Mice
  • Selenium / blood
  • Sodium Selenite / therapeutic use*
  • Time Factors


  • Blood Glucose
  • Glutathione Peroxidase
  • Glutathione Transferase
  • Glutathione
  • Selenium
  • Sodium Selenite