Explaining the bias in the 23S rRNA gene mutations associated with clarithromycin resistance in clinical isolates of Helicobacter pylori

Y J Debets-Ossenkopp; A B Brinkman; E J Kuipers; C M Vandenbroucke-Grauls; J G Kusters

doi:10.1128/AAC.42.10.2749

Explaining the bias in the 23S rRNA gene mutations associated with clarithromycin resistance in clinical isolates of Helicobacter pylori

Antimicrob Agents Chemother. 1998 Oct;42(10):2749-51. doi: 10.1128/AAC.42.10.2749.

Authors

Y J Debets-Ossenkopp¹, A B Brinkman, E J Kuipers, C M Vandenbroucke-Grauls, J G Kusters

Affiliation

¹ Department of Clinical Microbiology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands. yj.debets@azvu.nl

Abstract

A single point mutation in the 23S rRNA gene of Helicobacter pylori is known to confer resistance to clarithromycin. Most prevalent among clarithromycin-resistant clinical H. pylori isolates are the mutations from A-2142 to G and A-2143 to G in the 23S rRNA gene. The bias in the 23S rRNA gene mutations conferring clarithromycin resistance may result from the higher MIC, stability of resistance, and growth rate found for the strains with the above-mentioned mutations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Clarithromycin / pharmacology*
Drug Resistance, Microbial
Helicobacter pylori / drug effects*
Helicobacter pylori / genetics
Humans
Point Mutation*
RNA, Bacterial / genetics*
RNA, Ribosomal, 23S / genetics*

Substances

Anti-Bacterial Agents
RNA, Bacterial
RNA, Ribosomal, 23S
Clarithromycin