Methamphetamine-induced increase in striatal NF-kappaB DNA-binding activity is attenuated in superoxide dismutase transgenic mice

Brain Res Mol Brain Res. 1998 Oct 1;60(2):305-9. doi: 10.1016/s0169-328x(98)00188-0.

Abstract

Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-kappaB activity. Striatal NF-kappaB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-kappaB activity was significantly attenuated in Cu, Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-kappaB DNA-binding during this drug-induced toxic process.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Nucleus / metabolism
  • Corpus Striatum / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Dose-Response Relationship, Drug
  • Gene Dosage
  • Gene Expression Regulation* / drug effects
  • Heterozygote
  • Homozygote
  • Humans
  • Methamphetamine / pharmacology*
  • Mice
  • Mice, Transgenic
  • NF-kappa B / genetics*
  • NF-kappa B / metabolism
  • Reactive Oxygen Species
  • Superoxide Dismutase / genetics
  • Superoxide Dismutase / metabolism*

Substances

  • DNA-Binding Proteins
  • NF-kappa B
  • Reactive Oxygen Species
  • Methamphetamine
  • Superoxide Dismutase