Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-kappaB activity. Striatal NF-kappaB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-kappaB activity was significantly attenuated in Cu, Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-kappaB DNA-binding during this drug-induced toxic process.
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