[The significance of endothelial adhesion molecules in heart surgery]

Swiss Surg. 1998:Suppl 2:31-4.
[Article in German]


Myocardial ischemia and reperfusion is a common event in cardiovascular surgery patients. The endothelium has been shown to play a key role in the injury suffered after ischemia and reperfusion. When endothelial cells became hypoxic followed by reoxygenation they become activated to express endothelial adhesion molecules followed by the migration of neutrophils into the tissue. These changes may contribute to the early postoperatively myocardial dysfunction. An increased understanding of the interaction between leukocytes and endothelium may allow to develop new therapies in future.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Cell Adhesion Molecules / physiology*
  • Endothelium, Vascular / physiopathology*
  • Heart Diseases / physiopathology
  • Heart Diseases / surgery*
  • Humans
  • Myocardial Reperfusion Injury / diagnosis*
  • Myocardial Reperfusion Injury / physiopathology
  • Neutrophils / physiology


  • Cell Adhesion Molecules