Acne is an eminently curable disease. If therapeutic intervention sets in timely, scar formation can be prevented. Therapeutic modalities include the topical agents that should always be combined, and systemic agents, of which Isotretionoin is of particular importance. Isotretinoin is the only agent that can induce a complete clearing of acne lesions in 60 to 80% of cases. Adjuvant therapies, such as local injections, incisions, and peelings, are valuable tools in everyday practice and may accelerate the clearing of acne lesions. The treatment of acne is a long term endeavour that needs to be individually tuned to each patients' needs.