A Superfamily of Proteins That Contain the Cold-Shock Domain

Trends Biochem Sci. 1998 Aug;23(8):286-90. doi: 10.1016/s0968-0004(98)01255-9.

Abstract

Members of a family of cold-shock proteins (CSPs) are found throughout the eubacterial domain and appear to function as RNA-chaperones. They have been implicated in various cellular processes, including adaptation to low temperatures, cellular growth, nutrient stress and stationary phase. The discovery of a domain--the cold-shock domain--that shows strikingly high homology and similar RNA-binding properties to CSPs in a growing number of eukaryotic nucleic-acid-binding proteins suggests that these proteins have an ancient origin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Proteins / chemistry
  • Bacterial Proteins / physiology*
  • Cold Temperature*
  • Eukaryotic Cells / physiology
  • Evolution, Molecular*
  • Gene Expression Regulation, Bacterial
  • Models, Molecular
  • Protein Conformation
  • RNA Processing, Post-Transcriptional
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / physiology*
  • Transcription Factors / chemistry
  • Transcription Factors / physiology
  • Xenopus Proteins*

Substances

  • Bacterial Proteins
  • RNA-Binding Proteins
  • Transcription Factors
  • Xenopus Proteins
  • YBX2 protein, Xenopus
  • cold-shock protein CspB, Bacteria