Osteoporosis in patients with cystic fibrosis

Clin Chest Med. 1998 Sep;19(3):555-67. doi: 10.1016/s0272-5231(05)70100-3.


Decreased bone density and increased risk of fractures are seen in patients with cystic fibrosis. Suboptimal vitamin D levels, nutrition problems, hypogonadism, inactivity, corticosteroid use, and cytokines may contribute to the low bone mass seen in these patients. Treatment recommendations must be individualized and may include nutrition, vitamin D, estrogen or testosterone, and exercise. In high-risk patients calcitonin or growth hormone could be considered.

Publication types

  • Review

MeSH terms

  • Absorptiometry, Photon
  • Cystic Fibrosis / complications*
  • Cystic Fibrosis / physiopathology
  • Cystic Fibrosis / surgery
  • Fractures, Bone / complications
  • Glucocorticoids / metabolism
  • Humans
  • Lung Transplantation / physiology
  • Osteoporosis / complications*
  • Osteoporosis / diagnosis
  • Osteoporosis / physiopathology
  • Vitamin D / metabolism


  • Glucocorticoids
  • Vitamin D