Impact of recurrent nephrotic syndrome after renal transplantation in young patients

Pediatr Nephrol. 1998 Sep;12(7):529-33. doi: 10.1007/s004670050499.


Recurrent disease is a frequent complication of patients transplanted for steroid-resistant nephrotic syndrome associated with focal segmental glomerulosclerosis. Its long-term prognosis has rarely been studied. We examined 39 patients aged 4-25 (mean 13.5) years at the time of first transplantation (TX). Twelve of these (30%) developed nephrotic syndrome after the first TX and 2 of 8 after the second TX. The mean observation period from first TX to last observation with a functioning graft or graft loss was 5.4 (0.1-19.3) years. We confirmed that recurrent disease is associated with older age at onset of the primary disease, shorter time from onset to end-stage renal disease, and diffuse mesangial proliferation in the initial kidney biopsy. Remissions occurred in all 3 children undergoing early repeated plasma exchange and in 1 adolescent following introduction of cyclosporin A 7 years after TX. At last observation 42% of relapsing and 48% of non-relapsing patients with a similar follow-up period had a functioning first graft. Median first graft survival was almost identical in the relapsing and the non-relapsing patients (4.3 vs. 4.2 years). Histological lesions of focal glomerulosclerosis were detected in the posttransplant biopsies of only 3 patients. In conclusion, young patients with nephrotic syndrome associated with focal segmental sclerosis have a similar graft survival with and without recurrence of the nephrotic syndrome.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Cyclosporine / therapeutic use
  • Drug Resistance
  • Female
  • Glomerulosclerosis, Focal Segmental / complications*
  • Graft Survival
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Kidney / pathology
  • Kidney / physiopathology
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / pathology
  • Kidney Transplantation / pathology*
  • Male
  • Nephrotic Syndrome / etiology
  • Nephrotic Syndrome / pathology*
  • Nephrotic Syndrome / physiopathology
  • Nephrotic Syndrome / surgery
  • Plasma Exchange
  • Prognosis
  • Recurrence
  • Steroids / therapeutic use


  • Immunosuppressive Agents
  • Steroids
  • Cyclosporine