Cerebrospinal fluid--physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases

Mult Scler. 1998 Jun;4(3):99-107. doi: 10.1177/135245859800400302.


The state of the art in routine CSF analysis is reviewed with particular reference to multiple sclerosis regarding: (1) The physiology and pathophysiology of blood-CSF barrier function and dysfunction with the CSF flow rate as main modulator of blood- and brain-derived protein concentrations in CSF; (2) The neuroimmunological aspects regarding (a) patterns of disease-related immunoglobulin class response (IgG, IgA, IgM) in actual Reiber graphs with reference to specific parameters and optional tests, and (b) the oligoclonal, polyspecific antibody synthesis in brain; (3) Particular marker proteins in CSF and blood for differential diagnosis of neurological diseases; (4) Mathematical base for evaluations of CSF data with an example of a multiple sclerosis patient for calculation of intrathecal immunoglobulin and antibody synthesis as well as Antibody Index.

Publication types

  • Review

MeSH terms

  • Biomarkers / chemistry
  • Blood-Brain Barrier / physiology*
  • Cerebrospinal Fluid Proteins / analysis
  • Cerebrospinal Fluid Proteins / physiology*
  • Data Interpretation, Statistical*
  • Diagnosis, Differential
  • Humans
  • Nervous System Diseases / diagnosis*
  • Neuroimmunomodulation


  • Biomarkers
  • Cerebrospinal Fluid Proteins