Fibroblast precursors in normal and irradiated mouse hematopoietic organs

Exp Hematol. 1976 Sep;4(5):267-74.


Using the in vitro colony assay, clonogenic fibroblast precursor cells (CFU-F) were detected in the bone marrow, spleen and thymus from adult mice. The survival curve for CFU-F of mouse bone marrow irradiated in vitro has a D0 of 220 r. Regeneration of bone marrow CFU-F after whole-body irradiation with 150 r is characterized by a marked secondary loss and post-irradiation lag and dip, lasting 6 days, followed by return to normal values by about the 25th day. This pattern of post-radiation recovery of CFU-F is similar to that of the CFU-s. In addition, during the first 6 hours following irradiation the number of CFU-F increased approximately twofold.

MeSH terms

  • Animals
  • Bone Marrow / radiation effects*
  • Bone Marrow Cells*
  • Cell Count
  • Cell Division / radiation effects
  • Clone Cells / radiation effects
  • Fibroblasts* / radiation effects
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Mice, Nude
  • Spleen / cytology
  • Spleen / radiation effects*
  • Thymus Gland / cytology
  • Thymus Gland / radiation effects*