Pseudotumour of the tongue caused by herpes simplex virus type 2 in an HIV-1 infected immunosuppressed patient

Br J Dermatol. 1998 Jul;139(1):118-21. doi: 10.1046/j.1365-2133.1998.02327.x.


An HIV-1 infected immunosuppressed patient (CD4+ cell counts: 382 cells/microL; viral load 94,000 copies/mL) with recurrent perianal herpes simplex virus type 2 (HSV-2) infections is described, showing an unusual exophytic tumour resembling a squamous cell carcinoma in the lateral part of the tongue. He also had persistent facial herpes infection, oral candidosis, oral hairy leukoplakia and lymphadenopathy. The presence of HSV-2 was detected by polymerase chain reaction both in smears and in a tissue biopsy taken from the involved tongue area. Treatment with brivudin, a new oral virustatic drug, led to rapid regression of the tumour.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / complications*
  • Adult
  • Antiviral Agents / therapeutic use
  • Bromodeoxyuridine / analogs & derivatives
  • Bromodeoxyuridine / therapeutic use
  • Granuloma, Plasma Cell / drug therapy
  • Granuloma, Plasma Cell / virology*
  • HIV-1*
  • Herpes Genitalis / complications*
  • Humans
  • Immunocompromised Host
  • Male
  • Tongue Diseases / drug therapy
  • Tongue Diseases / virology*


  • Antiviral Agents
  • brivudine
  • Bromodeoxyuridine