Juvenile hormone analogue counteracts growth stimulation and inhibition by ecdysones in clonal Drosophila cell line

Experientia. 1976 Oct 15;32(10):1272-4. doi: 10.1007/BF01953088.

Abstract

Depending on concentration, ecdysones either stimulate or inhibit proliferation of a clonal Drosophila cell line. Both effects are counteracted by ethyl dichlorofarnesoate, a juvenile hormone analogue, which by itself is growth inhibitory. Qualitatively no difference was seen between alpha- and beta-ecdysone.

MeSH terms

  • Cell Division / drug effects*
  • Cell Line
  • Dose-Response Relationship, Drug
  • Drosophila / drug effects*
  • Drug Interactions
  • Ecdysone / antagonists & inhibitors
  • Ecdysone / pharmacology*
  • Juvenile Hormones / pharmacology*

Substances

  • Juvenile Hormones
  • Ecdysone