Coagulopathy secondary to vitamin K deficiency in hyperemesis gravidarum

Obstet Gynecol. 1998 Oct;92(4 Pt 2):673-5. doi: 10.1016/s0029-7844(98)00150-1.


Background: Hyperemesis gravidarum is a condition of pregnancy characterized by excessive nausea and vomiting, which can be associated with malnutrition. Vitamin K deficiency is a known complication of malnutrition as well as a known cause of coagulopathy. To date, there is no reported case in the literature of vitamin K deficiency in hyperemesis gravidarum.

Case: A woman at 15 weeks' gestation presented with hyperemesis gravidarum complicated by an episode of severe epistaxis. Investigation revealed coagulopathy secondary to vitamin K deficiency. The coagulopathy resolved after vitamin K replacement, with complete correction of all clotting factors.

Conclusion: Vitamin K deficiency and coagulopathy should be considered in women with hyperemesis gravidarum who present with a bleeding diathesis. Prophylactic vitamin K replacement should be considered in cases in which hyperemesis is severe and protracted.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood Coagulation Disorders / etiology*
  • Female
  • Humans
  • Hyperemesis Gravidarum / complications*
  • Pregnancy
  • Vitamin K / therapeutic use
  • Vitamin K Deficiency / complications*
  • Vitamin K Deficiency / drug therapy


  • Vitamin K