EUS/FNA is an extremely precise method for sampling lesions surrounding the gastrointestinal tract. As experience widens, so do the indications for its use. However, as endoscopists explore ways to use this technique to improve patient care, a basic premise should be kept in mind: the information obtained should have the potential to affect patient management. There will undoubtedly be refinements in the application of EUS/FNA, but the future looks very promising indeed.