Abstract
We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4(+) T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4(+) T-cell depletion, consistent with mechanisms requiring productive infection.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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2,2'-Dipyridyl / analogs & derivatives
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2,2'-Dipyridyl / pharmacology
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CD4-Positive T-Lymphocytes / immunology*
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Disulfides / pharmacology
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HIV Envelope Protein gp120 / immunology
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HIV-1 / drug effects
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HIV-1 / immunology*
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HIV-1 / pathogenicity*
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Humans
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In Vitro Techniques
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Lymphopenia / etiology
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Lymphopenia / immunology
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Lymphopenia / virology
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Receptors, CXCR4 / physiology
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Virulence / drug effects
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Virulence / immunology
Substances
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Disulfides
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HIV Envelope Protein gp120
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Receptors, CXCR4
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2,2'-dipyridyl disulfide
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2,2'-Dipyridyl