Spirofungin, a new antifungal antibiotic from Streptomyces violaceusniger Tü 4113

J Antibiot (Tokyo). 1998 Aug;51(8):699-707. doi: 10.7164/antibiotics.51.699.

Abstract

A new secondary metabolite was detected in the culture filtrate and extracts of Streptomyces violaceusniger Tü 4113 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compound named spirofungin has a polyketide-spiroketal structure and shows various antifungal activities, particularly against yeasts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry*
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Chromatography, High Pressure Liquid
  • Fermentation
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Spiro Compounds / chemistry*
  • Spiro Compounds / isolation & purification*
  • Spiro Compounds / pharmacology
  • Streptomyces
  • Yeasts / drug effects

Substances

  • Antifungal Agents
  • Spiro Compounds
  • spirofungin A