Spirofungin, a new antifungal antibiotic from Streptomyces violaceusniger Tü 4113

A Höltzel; C Kempter; J W Metzger; G Jung; I Groth; T Fritz; H P Fiedler

doi:10.7164/antibiotics.51.699

Spirofungin, a new antifungal antibiotic from Streptomyces violaceusniger Tü 4113

J Antibiot (Tokyo). 1998 Aug;51(8):699-707. doi: 10.7164/antibiotics.51.699.

Authors

A Höltzel¹, C Kempter, J W Metzger, G Jung, I Groth, T Fritz, H P Fiedler

Affiliation

¹ Institut für Organische Chemie, Universität Tübingen, Germany.

PMID: 9766461
DOI: 10.7164/antibiotics.51.699

Abstract

A new secondary metabolite was detected in the culture filtrate and extracts of Streptomyces violaceusniger Tü 4113 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compound named spirofungin has a polyketide-spiroketal structure and shows various antifungal activities, particularly against yeasts.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemistry*
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Chromatography, High Pressure Liquid
Fermentation
Microbial Sensitivity Tests
Molecular Structure
Spiro Compounds / chemistry*
Spiro Compounds / isolation & purification*
Spiro Compounds / pharmacology
Streptomyces
Yeasts / drug effects

Substances

Antifungal Agents
Spiro Compounds
spirofungin A