The pathogenesis of HLA-B27 arthritis: role of HLA-B27 in bacterial defense

Am J Med Sci. 1998 Oct;316(4):257-63. doi: 10.1097/00000441-199810000-00006.


The way in which a host accommodates invasive facultative intracellular bacteria must be the key to the development of reactive arthritis. Investigators have analyzed the bacterial events at several levels: invasion into host cells, intracellular survival, translocation from the sites of infection to the joints, residence in the joints, and evasion of host defense. Because HLA-B27 is present in higher incidence in patients with reactive arthritis and is an essential gene in the related ankylosing spondylitis, the role of HLA-B27 in host defense is also assumed to be important in the development of reactive arthritis. This review summarizes the various studies in this field.

Publication types

  • Review

MeSH terms

  • Arthritis, Infectious / genetics
  • Arthritis, Infectious / immunology*
  • Arthritis, Reactive / genetics
  • Arthritis, Reactive / immunology*
  • Bacteria / pathogenicity
  • Bacterial Infections / genetics
  • Bacterial Infections / immunology*
  • Bacterial Physiological Phenomena
  • HLA-B27 Antigen / genetics
  • HLA-B27 Antigen / immunology*
  • Humans
  • Spondylitis, Ankylosing / genetics
  • Spondylitis, Ankylosing / immunology*


  • HLA-B27 Antigen