Transcriptional control: repression by local chromatin modification

Curr Biol. 1998 Sep 24;8(19):R683-6. doi: 10.1016/s0960-9822(98)70435-x.

Abstract

It is becoming increasingly clear that chromatin modification plays a fundamental part in transcriptional control. Recent studies provide new insights into how transcriptional repressors, in addition to blocking activators, may recruit repression complexes that include chromatin modification factors.

Publication types

  • Review

MeSH terms

  • Alcohol Oxidoreductases
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Cycle / physiology
  • Chromatin / genetics
  • Chromatin / metabolism
  • Chromatin / physiology*
  • Chromosomal Proteins, Non-Histone*
  • CpG Islands
  • DNA Methylation
  • DNA-Binding Proteins / physiology*
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / physiology
  • Gene Expression Regulation / physiology*
  • Histone Deacetylases*
  • Humans
  • Methyl-CpG-Binding Protein 2
  • Models, Genetic
  • Phosphoproteins / physiology
  • Proteins / physiology
  • Repressor Proteins / physiology
  • Saccharomyces cerevisiae Proteins*
  • Transcription Factors / physiology
  • Transcription, Genetic / physiology*
  • Zinc Fingers / physiology

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • MECP2 protein, human
  • MeCP1 histone deacetylase complex, human
  • Methyl-CpG-Binding Protein 2
  • Phosphoproteins
  • Proteins
  • Repressor Proteins
  • SIN3 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • gro protein, Drosophila
  • Alcohol Oxidoreductases
  • C-terminal binding protein
  • Histone Deacetylases