Naloxone-precipitated morphine withdrawal induced place aversions: effect of naloxone at 24 hours postmorphine

Pharmacol Biochem Behav. 1998 Nov;61(3):331-3. doi: 10.1016/s0091-3057(98)00104-x.


The aversive properties of naloxone-precipitated withdrawal from acutely administered morphine were assessed using the place-conditioning paradigm. The conditioned place aversion produced by naloxone (0.5-1.0 mg/kg, s.c.) after two conditioning trials was enhanced by pretreatment with morphine (20 mg/kg, s.c.) 24 h prior to the conditioning trial. Naloxone precipitated withdrawal from acutely administered morphine produces an aversive motivational state that becomes associated with place cues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Avoidance Learning / drug effects*
  • Male
  • Morphine / pharmacology*
  • Naloxone / pharmacology*
  • Narcotic Antagonists / pharmacology*
  • Narcotics / pharmacology*
  • Psychomotor Performance / drug effects
  • Psychomotor Performance / physiology
  • Rats
  • Rats, Sprague-Dawley
  • Substance Withdrawal Syndrome*
  • Taste


  • Narcotic Antagonists
  • Narcotics
  • Naloxone
  • Morphine