Influence of Coccinia indica on certain enzymes in glycolytic and lipolytic pathway in human diabetes

Indian J Med Sci. 1998 Apr;52(4):143-6.


Dried extract of C Indica in doses of 500 mgm/kg body weight were administered orally to 30 diabetic patients for six weeks. Blood samples were collected 15 minutes after administration of 10 IU heparin for estimation of LPL, before and after treatment with C. Indica Non heparinised samples were utilized for estimation for G-6-p (ase), LDH and blood sugar. Severity of disease were assessed by the findings of blood sugar level. Mild diabetes had no effect on LPL, LDH and G-6-P (ase). But, reduced activity of enzyme LPL and raised level of G-6-P (ase) and LDH in plasma of severe diabetics were found to be highly significant (p < 0.001). The alteration in these parameters in untreated diabetics were restored after treatment with C. indica Hence, it can be postulated that the ingredients present in the extract of C. indica, act like insulin, correcting the elevated enzymes G-6-p (ase), LDH in glycolytic pathway and restore the LPL activity in lypolytic pathway with the control of hyperglycemia in diabetes.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Diabetes Mellitus / diagnosis
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / enzymology*
  • Female
  • Glucose-6-Phosphatase / metabolism
  • Glycolysis / drug effects*
  • Humans
  • L-Lactate Dehydrogenase / drug effects
  • L-Lactate Dehydrogenase / metabolism
  • Lipolysis / drug effects*
  • Lipoprotein Lipase / drug effects
  • Lipoprotein Lipase / metabolism
  • Male
  • Plant Extracts / therapeutic use*
  • Reference Values


  • Plant Extracts
  • L-Lactate Dehydrogenase
  • Lipoprotein Lipase
  • Glucose-6-Phosphatase