Intrasphincteric injection of botulinum toxin is effective in long-term treatment of esophageal achalasia

Muscle Nerve. 1998 Nov;21(11):1540-2. doi: 10.1002/(sici)1097-4598(199811)21:11<1540::aid-mus27>3.0.co;2-2.

Abstract

We investigated the long-term efficacy and safety of intrasphincteric injections of botulinum toxin (100 U) in 57 patients with esophageal achalasia. One month after treatment, 50 patients had improved (88%); both symptom score and LES pressure were significantly reduced (P < 0.001). After a mean follow-up of 24+/-15 months (range 6-48), 43 patients (75%) are still in remission, although repeat injections of toxin were needed to achieve a stable effect on symptoms.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Dyskinesia Agents / therapeutic use*
  • Botulinum Toxins / therapeutic use*
  • Child
  • Esophageal Achalasia / drug therapy*
  • Esophagogastric Junction
  • Female
  • Humans
  • Injections
  • Male
  • Middle Aged
  • Remission Induction
  • Time Factors
  • Treatment Outcome

Substances

  • Anti-Dyskinesia Agents
  • Botulinum Toxins