Trimethoxypsoralen in vitiligo

Int J Dermatol. 1976 Nov;15(9):690-3. doi: 10.1111/j.1365-4362.1976.tb01830.x.


The treatment of vitiligo has been unsatisfactory. Introduction of systemic furocoumarins to treatment regimens has given very promising results. Trimethylpsoralen has been found to be more potent than 8-methoxypsoralen. In cases studied, ultraviolet irradiation of affected sites following topical application of trimethylpsoralen was found to hasten the process of repigmentation. Simultaneous treatment of underlying disease produced a quicker response followed by sustained relief.

MeSH terms

  • Adult
  • Child
  • Coumarins / therapeutic use*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Methoxsalen / therapeutic use
  • Ointments
  • Phototherapy
  • Trioxsalen / administration & dosage
  • Trioxsalen / therapeutic use*
  • Vitiligo / drug therapy*
  • Vitiligo / therapy


  • Coumarins
  • Ointments
  • Methoxsalen
  • Trioxsalen