An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms

Mol Psychiatry. 1998 Sep;3(5):449-51. doi: 10.1038/


A functional polymorphism in the regulatory region of the serotonin transporter gene has been reported to be associated with anxiety-related personality traits. We attempted to replicate this finding in an association study involving 759 Caucasians selected from the general Australian population. We found no associations with personality traits (including neuroticism, negative affect and behavioral inhibition), anxiety and depressive symptoms, or alcohol misuse.

MeSH terms

  • Alcoholism / genetics
  • Anxiety / genetics
  • Australia
  • Carrier Proteins / genetics*
  • Depressive Disorder / genetics
  • European Continental Ancestry Group / genetics
  • Gene Frequency
  • Genotype
  • Humans
  • Membrane Glycoproteins / genetics*
  • Membrane Transport Proteins*
  • Mental Disorders / genetics*
  • Nerve Tissue Proteins / genetics
  • Neurotic Disorders / genetics*
  • Personality / genetics
  • Personality Disorders / genetics*
  • Polymorphism, Genetic*
  • Regulatory Sequences, Nucleic Acid
  • Serotonin Plasma Membrane Transport Proteins


  • Carrier Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins