Adult blacklegged ticks, Ixodes scapularis Say, collected from forested sites in Dutchess County, NY, were tested for infection with the etiologic agents of Lyme disease, Borrelia burgdorferi Johnson, Schmid, Hyde, Steigerwalt & Brenner, and human granulocytic ehrlichiosis (HGE). Rates of infection with the 2 pathogens were high and independent of one another, confirming prior findings and suggesting that a variety of hosts may be competent reservoirs of the HGE agent.