Adjunctive use of a subgingival controlled-release chlorhexidine chip reduces probing depth and improves attachment level compared with scaling and root planing alone

J Periodontol. 1998 Sep;69(9):989-97. doi: 10.1902/jop.1998.69.9.989.


The present studies evaluated the efficacy of a controlled-release biodegradable chlorhexidine (CHX) (2.5 mg) chip when used as an adjunct to scaling and root planing on reducing probing depth (PD) and improving clinical attachment level (CAL) in adult periodontitis. Two double-blind, randomized, placebo-controlled multi-center clinical trials (5 centers each) were conducted; pooled data are reported from all 10 centers (447 patients). At baseline, following 1 hour of scaling and root planing (SRP) in patients free of supragingival calculus, the chip was placed in target sites with PD 5 to 8 mm which bled on probing. Chip placement was repeated at 3 and/or 6 months if PD remained > or = 5 mm. Study sites in active chip subjects received either CHX chip plus SRP or SRP alone (to maintain study blind). Sites in placebo chip subjects received either placebo chip plus SRP or SRP alone. Examinations were performed at baseline; 7 days; 6 weeks; and 3, 6, and 9 months. At 9 months significant reductions from baseline favoring the chlorhexidine chip compared with both control treatments were observed with respect to PD (chlorhexidine chip plus SRP, 0.95 +/- 0.05 mm; SRP alone, 0.65 +/- 0.05 mm, P < 0.001; placebo chip plus SRP, 0.69 +/- 0.05 mm, P < 0.001) and CAL (chlorhexidine chip plus SRP, 0.75 +/- 0.06 mm; SRP alone, 0.58 +/- 0.06 mm, P < 0.05; placebo chip plus SRP, 0.55 +/- 0.06 mm, P < 0.05). The proportion of patients who evidenced a PD reduction from baseline of 2 mm or more at 9 months was significantly greater in the chlorhexidine chip group (19%) compared with SRP controls (8%) (P < 0.05). Adverse effects were minor and transient toothache, including pain, tenderness, aching, throbbing, soreness, discomfort, or sensitivity was the only adverse effect that was higher in the chlorhexidine group as compared to placebo (P = 0.042). These data demonstrate that the adjunctive use of the chlorhexidine chip results in a significant reduction of PD when compared with both SRP alone or the adjunctive use of a placebo chip. These multi-center randomized control trials suggest that the chlorhexidine chip is a safe and effective adjunctive chemotherapy for the treatment of adult periodontitis.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anti-Infective Agents, Local / administration & dosage
  • Anti-Infective Agents, Local / adverse effects
  • Anti-Infective Agents, Local / therapeutic use*
  • Biodegradation, Environmental
  • Chlorhexidine / administration & dosage
  • Chlorhexidine / adverse effects
  • Chlorhexidine / therapeutic use*
  • Combined Modality Therapy
  • Delayed-Action Preparations
  • Dental Calculus / therapy
  • Dental Scaling*
  • Double-Blind Method
  • Drug Implants
  • Female
  • Follow-Up Studies
  • Gingival Hemorrhage / drug therapy
  • Gingival Hemorrhage / therapy
  • Humans
  • Male
  • Middle Aged
  • Periodontal Attachment Loss / drug therapy*
  • Periodontal Attachment Loss / therapy
  • Periodontal Pocket / drug therapy*
  • Periodontal Pocket / therapy
  • Periodontitis / drug therapy
  • Periodontitis / therapy
  • Placebos
  • Root Planing*
  • Safety


  • Anti-Infective Agents, Local
  • Delayed-Action Preparations
  • Drug Implants
  • Placebos
  • Chlorhexidine