The collagen-platelet interaction

Curr Opin Hematol. 1998 Sep;5(5):314-20. doi: 10.1097/00062752-199809000-00002.

Abstract

Collagen-platelet interaction, occurring in hemostasis but also a cause of thrombosis, is a two-step process of adhesion and activation involving the sequential recognition of distinct receptors. Adhesion involves first the reversible recognition of collagen-bound von Willebrand factor by the platelet receptor complex Gp Ib/IX/V, followed by direct interaction between collagen and the platelet integrin receptor alpha2beta1, which binds to specific sequences in collagen in which the GER motif appears important. Platelet activation then follows from the recognition by the receptor Gp VI of GPP* sequences in collagen, culminating in signalling events unique to collagen as a platelet agonist: Gp VI leads via the novel platelet Fc receptor gamma-chain to p72syk and phospholipase Cgamma2.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Platelets / metabolism*
  • Collagen / metabolism*
  • Humans
  • Platelet Adhesiveness
  • Platelet Membrane Glycoproteins / metabolism

Substances

  • Platelet Membrane Glycoproteins
  • platelet membrane glycoprotein VI
  • Collagen