Discovery of simian virus 40 (SV40) and its relationship to poliomyelitis virus vaccines
- PMID: 9776239
Discovery of simian virus 40 (SV40) and its relationship to poliomyelitis virus vaccines
Abstract
Simian Virus 40 (SV40) was discovered in 1959 as a covert contaminant of poliovirus vaccines prepared using Macacus monkey renal cell cultures. This inapparent polyoma virus of monkeys was detected using Cercopithecus renal cell cultures and was eliminated from poliovaccines. There has been no evidence to implicate SV40 virus of vaccine origin in long- or short-term consequences in human subjects. Of importance, SV40 virus provided a new model for basic studies of viral pathogenesis and for cell transformation and neoplasia. Neoplastic transformation is fixed on the promiscuous binding of SV40 large T antigen to anti-oncogene cellular protein elements. SV40 also served as a valuable model for defining the immunology of virus-induced cancer and in its prevention and cure. Further, it has been a prime tool for elucidating the molecular details of eukaryotic cell processes. Numerous techniques now used in molecular biology were pioneered in the SV40 system. The SV40 promoter is commonly used in vector expression constructs and it has continued to be a model to develop new tools for site-specific mutagenesis. The virus has been critically important to studies in modern genetics and in molecular biology.
Similar articles
-
Examination of poliovaccines for the presence of SV40 sequences.Dev Biol Stand. 1998;94:221-5. Dev Biol Stand. 1998. PMID: 9776243 Review.
-
Simian virus 40, poliovirus vaccines, and human cancer: research progress versus media and public interests.Bull World Health Organ. 2000;78(2):195-8. Bull World Health Organ. 2000. PMID: 10743284 Free PMC article. Review.
-
Unique strains of SV40 in commercial poliovaccines from 1955 not readily identifiable with current testing for SV40 infection.Cancer Res. 1999 Dec 15;59(24):6103-8. Cancer Res. 1999. PMID: 10626798
-
Examination of poliovirus vaccine preparations for SV40 sequences.Biologicals. 1999 Mar;27(1):1-10. doi: 10.1006/biol.1998.0170. Biologicals. 1999. PMID: 10441397
-
Is there a role for SV40 in human cancer?J Clin Oncol. 2006 Sep 10;24(26):4356-65. doi: 10.1200/JCO.2005.03.7101. J Clin Oncol. 2006. PMID: 16963733 Review.
Cited by
-
Functional Domains of the Early Proteins and Experimental and Epidemiological Studies Suggest a Role for the Novel Human Polyomaviruses in Cancer.Front Microbiol. 2022 Feb 18;13:834368. doi: 10.3389/fmicb.2022.834368. eCollection 2022. Front Microbiol. 2022. PMID: 35250950 Free PMC article. Review.
-
Print Me an Organ? Ethical and Regulatory Issues Emerging from 3D Bioprinting in Medicine.Sci Eng Ethics. 2018 Feb;24(1):73-91. doi: 10.1007/s11948-017-9874-6. Epub 2017 Feb 9. Sci Eng Ethics. 2018. PMID: 28185142
-
Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic.Eur Respir Rev. 2015 Mar;24(135):115-31. doi: 10.1183/09059180.00007014. Eur Respir Rev. 2015. PMID: 25726562 Free PMC article. Review.
-
Extraneous agent detection in vaccines--a review of technical aspects.Biologicals. 2012 Jul;40(4):225-30. doi: 10.1016/j.biologicals.2012.04.004. Epub 2012 May 9. Biologicals. 2012. PMID: 22575785 Free PMC article. Review.
-
[Merkel cell polyomavirus in the pathogenesis of non-melanoma skin cancer].Pathologe. 2009 Dec;30 Suppl 2:217-20. doi: 10.1007/s00292-009-1222-4. Pathologe. 2009. PMID: 19921198 German.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical