ECG conduction delays associated with massive bupropion overdose

J Toxicol Clin Toxicol. 1998;36(6):595-8. doi: 10.3109/15563659809028055.


Background: Bupropion, a relatively new antidepressant, is highly regarded for its safety profile in therapeutic doses and in the overdose. Seizure is the primary adverse reaction associated with bupropion overdoses. Clinically significant cardiovascular complications are rare.

Case report: We report the case of an adult male who ingested 9 g bupropion and developed neurologic toxicity as well as intraventricular conduction disturbances on electrocardiogram. Cardiac monitoring of these patients should be considered.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antidepressive Agents, Second-Generation / poisoning*
  • Arrhythmias, Cardiac / chemically induced
  • Arrhythmias, Cardiac / drug therapy
  • Bupropion / poisoning*
  • Delirium / chemically induced
  • Delirium / drug therapy
  • Drug Overdose
  • Electrocardiography / drug effects
  • Heart Conduction System / drug effects*
  • Heart Conduction System / physiopathology
  • Humans
  • Male
  • Seizures / chemically induced
  • Seizures / drug therapy
  • Treatment Outcome


  • Antidepressive Agents, Second-Generation
  • Bupropion