The pathogenesis of psoriasis and the mechanism of action of tazarotene

J Am Acad Dermatol. 1998 Oct;39(4 Pt 2):S129-33. doi: 10.1016/s0190-9622(98)70309-3.

Abstract

The 3 major features of psoriasis--abnormal differentiation of keratinocytes, hyperproliferation of keratinocytes, and infiltration of inflammatory components into the skin--can be quantified by measuring levels of certain biochemical markers. Psoriasis is associated with upregulation or downregulation of several of these markers. Tazarotene helps to normalize the levels of the markers, thereby bringing about clinical improvement.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Administration, Cutaneous
  • Biomarkers
  • Epidermal Growth Factor / metabolism
  • Humans
  • Keratinocytes / metabolism
  • Keratolytic Agents / pharmacology*
  • Nicotinic Acids / pharmacology*
  • Psoriasis / metabolism*
  • Psoriasis / pathology*

Substances

  • Biomarkers
  • Keratolytic Agents
  • Nicotinic Acids
  • Epidermal Growth Factor
  • tazarotene