Physiology and healing dynamics of chronic cutaneous wounds

Am J Surg. 1998 Aug;176(2A Suppl):26S-38S. doi: 10.1016/s0002-9610(98)00183-4.


In the last few decades, a great deal of progress has been made in understanding the cellular and biochemical interplay that comprises the normal wound healing response. This response is a complex process involving intricate interactions among a variety of different cell types, structural proteins, growth factors, and proteinases. The normal wound repair process consists of three phases--inflammation, proliferation, and remodeling--that occur in a predictable sequence and comprise a series of cellular and biochemical events. A review of the biochemical and physiologic processes that regulate wound healing and the cascade of cellular events that gives rise to the healing process is presented here.

Publication types

  • Review

MeSH terms

  • Chronic Disease
  • Collagen / biosynthesis
  • Diabetic Foot / physiopathology*
  • Fibroblasts / physiology
  • Growth Substances / pharmacology
  • Humans
  • Inflammation
  • Skin / injuries
  • Wound Healing / physiology*


  • Growth Substances
  • Collagen