Signaling to p53: Breaking the MDM2-p53 Circuit

Cell. 1998 Oct 2;95(1):5-8. doi: 10.1016/s0092-8674(00)81774-2.

Publication types

  • Review

MeSH terms

  • Animals
  • Cyclin-Dependent Kinase Inhibitor p16 / genetics
  • Humans
  • Nuclear Proteins*
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-mdm2
  • Signal Transduction*
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Cyclin-Dependent Kinase Inhibitor p16
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Tumor Suppressor Protein p53
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2