Interdependence of mycobacterial iron regulation, oxidative-stress response and isoniazid resistance

Trends Microbiol. 1998 Sep;6(9):354-8. doi: 10.1016/s0966-842x(98)01307-9.

Abstract

Iron is an essential cofactor for vital functions in microorganisms. Bacterial pathogens have developed efficient iron-acquisition systems to counteract the defensive sequestration of iron by their hosts. In mycobacteria, the recently described protein, IdeR, negatively controls iron-uptake systems. This protein also has a role in the oxidative-stress response, as well as in resistance to the frontline antimycobacterial drug isoniazid.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antitubercular Agents / metabolism
  • Antitubercular Agents / pharmacology*
  • Bacterial Proteins / metabolism
  • Drug Resistance, Microbial
  • Iron / pharmacokinetics*
  • Isoniazid / metabolism
  • Isoniazid / pharmacology*
  • Mycobacterium / drug effects*
  • Mycobacterium / genetics
  • Mycobacterium / physiology*
  • Oxidative Stress / physiology*
  • Siderophores / physiology

Substances

  • Antitubercular Agents
  • Bacterial Proteins
  • Siderophores
  • Iron
  • Isoniazid