Kinase-phosphatase competition regulates Bacillus subtilis development

Trends Microbiol. 1998 Sep;6(9):366-70. doi: 10.1016/s0966-842x(98)01350-x.


The major regulator of sporulation initiation in Bacillus subtilis is the phosphorelay, a multicomponent signal transduction system. A myriad of signals, both positive and negative, from the environment, cell cycle and metabolism is received and interpreted by the phosphorelay and integrated through the opposing activity of protein kinases and protein aspartate phosphatases to create an extremely sophisticated regulatory network.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacillus subtilis / enzymology
  • Bacillus subtilis / growth & development
  • Bacillus subtilis / physiology*
  • Phosphoric Monoester Hydrolases / metabolism*
  • Protein Kinases / metabolism*
  • Signal Transduction / physiology
  • Spores
  • Transcriptional Activation


  • Protein Kinases
  • Phosphoric Monoester Hydrolases