Signaling by integrin receptors

Oncogene. 1998 Sep 17;17(11 Reviews):1365-73. doi: 10.1038/sj.onc.1202172.

Abstract

Adhesive interactions are critical for the proliferation, survival and function of all cells. Integrin receptors as the major family of adhesion receptors have been the focus of study for more than a decade. These studies have tremendously enhanced our understanding of the integrin-mediated adhesive interactions and have unraveled novel integrin functions in cell survival mechanisms and in the activation of divergent signaling pathways. The signals from integrin receptors are integrated from those originating from growth factor receptors in order to organize the cytoskeleton, stimulate cell proliferation and rescue cells from matrix detachment-induced programmed cell death. These functions are critical in the regulation of multiple processes such as tissue development, inflammation, angiogenesis, tumor cell growth and metastasis and programmed cell death.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Adhesion Molecules / metabolism
  • Cell Division / physiology*
  • Cell Movement
  • Cell Survival
  • Cell Transformation, Neoplastic
  • Cytoskeleton / metabolism*
  • Focal Adhesion Kinase 1
  • Focal Adhesion Protein-Tyrosine Kinases
  • GTP-Binding Proteins / metabolism
  • Humans
  • Integrins / metabolism*
  • Phosphatidylinositol 3-Kinases
  • Protein-Serine-Threonine Kinases*
  • Protein-Tyrosine Kinases / metabolism
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-akt
  • Receptors, Immunologic
  • Signal Transduction*
  • rho GTP-Binding Proteins

Substances

  • Cell Adhesion Molecules
  • Integrins
  • Proto-Oncogene Proteins
  • Receptors, Immunologic
  • Phosphatidylinositol 3-Kinases
  • Protein-Tyrosine Kinases
  • Focal Adhesion Kinase 1
  • Focal Adhesion Protein-Tyrosine Kinases
  • PTK2 protein, human
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • GTP-Binding Proteins
  • rho GTP-Binding Proteins