Genetic analysis of mammalian G-protein signalling

Oncogene. 1998 Sep 17;17(11 Reviews):1375-81. doi: 10.1038/sj.onc.1202173.

Abstract

Heterotrimeric G-proteins are important signalling proteins which function in all cells of the mammalian organism. Inactivating mutations in a variety of G-protein alpha-subunit genes in mice resulted in mostly unexpected phenotypes and have provided interesting new insight into their biological roles. Whereas the inactivation of some G alpha genes led to mild phenotypes suggesting the presence of redundant or compensatory mechanisms, other G-proteins appear to play highly specific biological or developmental roles. The purpose of this review is to summarize the current knowledge about G-protein functions based on gene-inactivation studies.

Publication types

  • Review

MeSH terms

  • Animals
  • GTP-Binding Protein alpha Subunit, Gi2
  • GTP-Binding Protein alpha Subunits, Gi-Go*
  • GTP-Binding Protein alpha Subunits, Gq-G11
  • GTP-Binding Protein alpha Subunits, Gs / genetics
  • GTP-Binding Protein alpha Subunits, Gs / metabolism
  • GTP-Binding Proteins / genetics*
  • GTP-Binding Proteins / metabolism*
  • Heterotrimeric GTP-Binding Proteins*
  • Humans
  • Mice
  • Mice, Mutant Strains*
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism
  • Signal Transduction*

Substances

  • Proto-Oncogene Proteins
  • GTP-Binding Proteins
  • G protein alpha 16
  • GNAI2 protein, human
  • GTP-Binding Protein alpha Subunit, Gi2
  • GTP-Binding Protein alpha Subunits, Gi-Go
  • GTP-Binding Protein alpha Subunits, Gq-G11
  • GTP-Binding Protein alpha Subunits, Gs
  • Gnai2 protein, mouse
  • Heterotrimeric GTP-Binding Proteins