Signaling by dual specificity kinases

Oncogene. 1998 Sep 17;17(11 Reviews):1447-55. doi: 10.1038/sj.onc.1202251.

Abstract

Dual specificity kinases that phosphorylate the Thr- and Tyr-residues within the TXY motif of MAP-kinases of play a central role in the regulation of various processes of cell growth. These dual specificity kinases also known as MAP kinase kinases are constituents of the sequential kinase signaling modules. Seven distinct mammalian MAP kinases kinases have been identified. Some of the unique signaling properties of these kinases are discussed here.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • MAP Kinase Kinase 1
  • MAP Kinase Kinase 2
  • MAP Kinase Kinase 3
  • MAP Kinase Kinase 4*
  • MAP Kinase Kinase 6
  • MAP Kinase Kinase 7
  • Mitogen-Activated Protein Kinase Kinases
  • Protein Kinases / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism*
  • Protein-Tyrosine Kinases / metabolism*
  • Signal Transduction*
  • Substrate Specificity

Substances

  • Intracellular Signaling Peptides and Proteins
  • MAP-kinase-activated kinase 5
  • Protein Kinases
  • MAP2K2 protein, human
  • Protein-Tyrosine Kinases
  • Protein-Serine-Threonine Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases
  • MAP Kinase Kinase 1
  • MAP Kinase Kinase 2
  • MAP Kinase Kinase 3
  • MAP Kinase Kinase 4
  • MAP Kinase Kinase 6
  • MAP Kinase Kinase 7
  • MAP2K1 protein, human
  • MAP2K3 protein, human
  • MAP2K4 protein, human
  • MAP2K6 protein, human
  • MAP2K7 protein, human
  • Mitogen-Activated Protein Kinase Kinases