Cell cycle targets of Ras/Raf signalling

Oncogene. 1998 Sep 17;17(11 Reviews):1457-62. doi: 10.1038/sj.onc.1202185.


The regulation of cell proliferation in multicellular organisms is a complex process, which is primarily regulated by external growth factors provided by surrounding cells. Once induced to proliferate, the passage through the mitotic cell cycle is directed by the components of the so called cell cycle machinery. Over the last years research on growth factor signal-transduction and the components of the cell cycle system has lead to a detailed knowledge of the mechanisms by which growth factors transmit their signals and of the relationship between the components of the cell cycle machinery. The remaining question how the growth factor mediated signal-transduction cascades couple with the cell cycle regulators has recently been a focus of interest.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / genetics*
  • Cell Cycle Proteins*
  • Cyclin D1 / genetics
  • Cyclin D1 / metabolism
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclin-Dependent Kinase Inhibitor p27
  • Cyclins / genetics
  • Cyclins / metabolism
  • Genes, myc
  • Genes, ras*
  • Humans
  • Microtubule-Associated Proteins / genetics
  • Microtubule-Associated Proteins / metabolism
  • Protein Tyrosine Phosphatases / metabolism
  • Proto-Oncogene Proteins c-raf / genetics*
  • Proto-Oncogene Proteins c-raf / metabolism*
  • Signal Transduction*
  • Tumor Suppressor Proteins*
  • cdc25 Phosphatases*


  • CDKN1A protein, human
  • Cell Cycle Proteins
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • Microtubule-Associated Proteins
  • Tumor Suppressor Proteins
  • Cyclin D1
  • Cyclin-Dependent Kinase Inhibitor p27
  • Proto-Oncogene Proteins c-raf
  • CDC25A protein, human
  • Protein Tyrosine Phosphatases
  • cdc25 Phosphatases