Organ specific induction of drug metabolizing enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat

Toxicol Appl Pharmacol. 1978 Apr;44(1):107-14. doi: 10.1016/0041-008x(78)90289-2.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aryl Hydrocarbon Hydroxylases / metabolism
  • Coumarins / metabolism
  • Cytochrome P-450 Enzyme System / metabolism
  • Dioxins / pharmacology*
  • Enzyme Induction / drug effects
  • Epoxide Hydrolases / metabolism
  • Glucuronosyltransferase / metabolism
  • Male
  • Microsomes / enzymology
  • NADPH-Ferrihemoprotein Reductase / metabolism
  • Organ Specificity
  • Pharmaceutical Preparations / metabolism*
  • Polychlorinated Dibenzodioxins / pharmacology*
  • Rats

Substances

  • Coumarins
  • Dioxins
  • Pharmaceutical Preparations
  • Polychlorinated Dibenzodioxins
  • Cytochrome P-450 Enzyme System
  • Aryl Hydrocarbon Hydroxylases
  • NADPH-Ferrihemoprotein Reductase
  • Glucuronosyltransferase
  • Epoxide Hydrolases