Genetics of susceptibility to Theiler's virus infection

Bioessays. 1998 Aug;20(8):627-33. doi: 10.1002/(SICI)1521-1878(199808)20:8<627::AID-BIES5>3.0.CO;2-F.


Theiler's virus is a picornavirus of mouse which causes an acute encephalomyelitis followed by a persistent infection of the white matter resulting in chronic inflammation and demyelination. This disease has been studied as a model for multiple sclerosis. Inbred strains of mice are either resistant--they clear the infection after the acute encephalomyelitis--or susceptible to persistent infection and demyelination. Susceptibility is a polygenic trait which has been analyzed using methods of association with "candidate" genes, and linkage analysis after a complete genome scan. The H-2Db gene is responsible for an efficient CTL response which makes some strains resistant. Non H-2 genes responsible for the susceptibility of other strains have been mapped by linkage analysis to the lfng and, possibly, the Mbp loci. The analysis of a set of congenic mice ruled out the possibility that the relevant gene codes for interferon gamma, and showed that the region around lfng probably contains two susceptibility genes. The analysis of mutant mice showed further that the Mbp gene, which codes for the myelin basic protein, has a major effect on viral persistence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovirus Infections / genetics
  • Cardiovirus Infections / physiopathology
  • Cardiovirus Infections / veterinary*
  • Demyelinating Diseases / genetics
  • Demyelinating Diseases / veterinary
  • Demyelinating Diseases / virology
  • Disease Susceptibility
  • Genetic Predisposition to Disease
  • Humans
  • Mice
  • Multiple Sclerosis / genetics
  • Multiple Sclerosis / physiopathology
  • Rodent Diseases / genetics
  • Rodent Diseases / physiopathology
  • Rodent Diseases / virology*
  • Theilovirus*