Accelerator mass spectrometry as a bioanalytical tool for nutritional research

Adv Exp Med Biol. 1998;445:397-410. doi: 10.1007/978-1-4899-1959-5_25.


Accelerator Mass Spectrometry is a mass spectrometric method of detecting long-lived radioisotopes without regard to their decay products or half-life. The technique is normally applied to geochronology, but is also available for bioanalytical tracing. AMS detects isotope concentrations to parts per quadrillion, quantifying labeled biochemicals to attomole levels in milligram-sized samples. Its advantages over non-isotopic and stable isotope labeling methods are reviewed and examples of analytical integrity, sensitivity, specificity, and applicability are provided.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium Isotopes / analysis
  • Carbon Isotopes / analysis
  • Carcinogens / analysis
  • Chemistry Techniques, Analytical / instrumentation*
  • Chromatography, High Pressure Liquid
  • Deuterium / analysis
  • Gas Chromatography-Mass Spectrometry*
  • Humans
  • Models, Biological*
  • Nutritional Physiological Phenomena*
  • Particle Accelerators*
  • Quinolines / urine
  • Radioactive Tracers*
  • Rats
  • Sensitivity and Specificity


  • Calcium Isotopes
  • Carbon Isotopes
  • Carcinogens
  • Quinolines
  • Radioactive Tracers
  • Deuterium
  • 2-amino-3,4-dimethylimidazo(4,5-f)quinoline