Widespread Occurrence of a Highly Conserved RING-H2 Zinc Finger Motif in the Model Plant Arabidopsis Thaliana

FEBS Lett. 1998 Oct 2;436(2):283-7. doi: 10.1016/s0014-5793(98)01143-0.

Abstract

Several novel Arabidopsis thaliana proteins containing a RING-H2 zinc finger motif were predicted after database searches. Alignment of 29 RING-H2 finger sequences shows that the motif is strikingly conserved in otherwise unrelated proteins. Only short, non-conserved polar/charged sequences distinguish these domains. The RING-H2 domain is most often present in multi-domain structures, a number of which are likely to contain a membrane-spanning region or an additional zinc finger. However, there are several small (126-200 residues) proteins consisting of an N-terminal domain, rich in aliphatic residues, and a C-terminal RING-H2 domain. Reverse-transcription PCR suggests that the RING-H2 genes are widely expressed at low levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Arabidopsis / genetics*
  • Conserved Sequence
  • Databases, Factual
  • Models, Molecular
  • Molecular Sequence Data
  • Plant Proteins / chemistry*
  • Plant Proteins / genetics
  • Protein Conformation*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Zinc Fingers*

Substances

  • Plant Proteins

Associated data

  • GENBANK/AF078683
  • GENBANK/AF078821
  • GENBANK/AF078822
  • GENBANK/AF078823
  • GENBANK/AF078824
  • GENBANK/AF078825
  • GENBANK/AF079178
  • GENBANK/AF079179
  • GENBANK/AF079180
  • GENBANK/AF079181
  • GENBANK/AF079182
  • GENBANK/AF079183
  • GENBANK/AF079184
  • GENBANK/AF079185
  • GENBANK/AF079186