Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors

Genomics. 1998 Sep 1;52(2):223-9. doi: 10.1006/geno.1998.5441.

Abstract

Growth hormone secretagogues (GHS) are a group of synthetic peptide and nonpeptide molecules that potently stimulate the release of GH from the anterior pituitary gland through the activation of a novel G-protein-coupled receptor (GPC-R), the GHS-R. In our search for GHS-R family members, we recently described the cloning of two related GPC-Rs, GPR38 and 39. In the present report, we detail the isolation of a new GPC-R (FM-3) from human and mouse with moderate sequence identity to both the GHS-R and neurotensin-R. FM-3 is expressed in a diverse set of tissues.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Line
  • Cloning, Molecular
  • DNA / chemistry
  • DNA / genetics
  • DNA, Complementary / chemistry
  • DNA, Complementary / genetics
  • GTP-Binding Proteins / metabolism*
  • Gene Expression
  • Humans
  • Membrane Proteins*
  • Mice
  • Molecular Sequence Data
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Receptors, Cell Surface / genetics*
  • Receptors, Cell Surface / metabolism
  • Receptors, G-Protein-Coupled*
  • Receptors, Ghrelin
  • Receptors, Neurotensin / genetics*
  • Receptors, Neurotransmitter*
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • T-Lymphocytes / chemistry
  • T-Lymphocytes / metabolism*
  • Tissue Distribution
  • Transfection

Substances

  • DNA, Complementary
  • Membrane Proteins
  • RNA, Messenger
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Receptors, Ghrelin
  • Receptors, Neurotensin
  • Receptors, Neurotransmitter
  • neuromedin U receptor
  • DNA
  • GTP-Binding Proteins

Associated data

  • GENBANK/AF044600
  • GENBANK/AF044601