The cholinergic locus: ChAT and VAChT genes

J Physiol Paris. 1998 Apr;92(2):145-7. doi: 10.1016/S0928-4257(98)80153-8.


The gene encoding the vesicular acetylcholine transporter has been localized within the first intron of the gene encoding choline acetyltransferase and is in the same transcriptional orientation. These two genes, whose products are required for the expression of the cholinergic phenotype, could therefore be coregulated. The promoters of both genes have been identified. The mechanisms that account for the regulation of the expression of both genes are now being investigated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylcholine / metabolism
  • Animals
  • Carrier Proteins / genetics*
  • Choline O-Acetyltransferase / genetics*
  • Gene Expression Regulation
  • Introns
  • Membrane Transport Proteins*
  • Promoter Regions, Genetic
  • Rats
  • Transcription, Genetic*
  • Vesicular Acetylcholine Transport Proteins
  • Vesicular Transport Proteins*


  • Carrier Proteins
  • Membrane Transport Proteins
  • Slc18a3 protein, rat
  • Vesicular Acetylcholine Transport Proteins
  • Vesicular Transport Proteins
  • Choline O-Acetyltransferase
  • Acetylcholine