The cholinergic locus: ChAT and VAChT genes

J Mallet; L Houhou; F Pajak; Y Oda; R Cervini; S Bejanin; S Berrard

doi:10.1016/S0928-4257(98)80153-8

The cholinergic locus: ChAT and VAChT genes

J Physiol Paris. 1998 Apr;92(2):145-7. doi: 10.1016/S0928-4257(98)80153-8.

Authors

J Mallet¹, L Houhou, F Pajak, Y Oda, R Cervini, S Bejanin, S Berrard

Affiliation

¹ CNRS, Laboratoire de Génétique de la Neurotransmission et des Processus Neurodégénératifs, Hôpital Pitié-Salpétrière, Paris, France.

PMID: 9782459
DOI: 10.1016/S0928-4257(98)80153-8

Abstract

The gene encoding the vesicular acetylcholine transporter has been localized within the first intron of the gene encoding choline acetyltransferase and is in the same transcriptional orientation. These two genes, whose products are required for the expression of the cholinergic phenotype, could therefore be coregulated. The promoters of both genes have been identified. The mechanisms that account for the regulation of the expression of both genes are now being investigated.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Acetylcholine / metabolism
Animals
Carrier Proteins / genetics*
Choline O-Acetyltransferase / genetics*
Gene Expression Regulation
Introns
Membrane Transport Proteins*
Promoter Regions, Genetic
Rats
Transcription, Genetic*
Vesicular Acetylcholine Transport Proteins
Vesicular Transport Proteins*

Substances

Carrier Proteins
Membrane Transport Proteins
Slc18a3 protein, rat
Vesicular Acetylcholine Transport Proteins
Vesicular Transport Proteins
Choline O-Acetyltransferase
Acetylcholine