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, 36 (7), 675-9

Subchronic Oral Hepatotoxicity of Turmeric in Mice--Histopathological and Ultrastructural Studies

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  • PMID: 9782784

Subchronic Oral Hepatotoxicity of Turmeric in Mice--Histopathological and Ultrastructural Studies

S V Kandarkar et al. Indian J Exp Biol.

Abstract

Dietary administration of the whole spice turmeric (0.2%, 1.0%, 5.0%) or ethanolic turmeric extract (ETE, 0.05%, 0.25%) for 14 days, at doses reported to be cancer preventive in model systems, were found to be hepatotoxic in mice. Histopathological evaluation showed coagulative necrosis accompanied by a zone of regenerating parenchymal cells of liver. The ultrastructural changes in liver parenchymal cells were non-specific reaction to injury. Results suggest mouse to be a susceptible species for turmeric induced toxicity.

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