Subchronic oral hepatotoxicity of turmeric in mice--histopathological and ultrastructural studies

Indian J Exp Biol. 1998 Jul;36(7):675-9.


Dietary administration of the whole spice turmeric (0.2%, 1.0%, 5.0%) or ethanolic turmeric extract (ETE, 0.05%, 0.25%) for 14 days, at doses reported to be cancer preventive in model systems, were found to be hepatotoxic in mice. Histopathological evaluation showed coagulative necrosis accompanied by a zone of regenerating parenchymal cells of liver. The ultrastructural changes in liver parenchymal cells were non-specific reaction to injury. Results suggest mouse to be a susceptible species for turmeric induced toxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Chemical and Drug Induced Liver Injury / etiology*
  • Chemical and Drug Induced Liver Injury / pathology
  • Condiments / adverse effects*
  • Curcuma
  • Female
  • Mice
  • Microscopy, Electron
  • Plant Extracts / adverse effects*


  • Plant Extracts
  • turmeric extract